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functional analysis

Functional analysis of coding and non-coding RNA usually involves the use of antisense oligonucleotides (ASO) for specific inhibition or knockdown of RNA targets in vitro and in vivo. Locked Nucleic Acids or LNA™-enhanced ASOs offer simple and efficient approaches for the study of RNA function and due to their high biological stability and activity, hold promising potential in therapeutic applications.

Exiqon offer highly potent LNA™ microRNA inhibitors and target site blockers as well as LNA™ GapmeRs for silencing mRNA and long non-coding RNA. Our comprehensive product range includes ASOs ideal for both in vitro and in vivo use.



Download In Vivo Guidelines

In Vivo Guidelines

Read about the key technologies enabling functional analysis of microRNA, mRNA and lncRNA in animal models. Topics include routes of administration, pharmacokinetics and biodistribution of antisense oligonucleotides. We also describe how to establish the optimal dose regime. Download In Vivo Guidelines

Development of antisense therapy for cystic fibrosis

Development of antisense therapy for cystic fibrosis

Dr. Magali Taulan is an associate professor at the University of Montpellier in France. Her lab has been using LNA™ antisense oligonucleotides that interfere with microRNAs to better understanding how CFTR expression is regulated.
Read more

OncomiR screening using Exiqon's microRNA Inhibitor Library

OncomiR screening using Exiqon's microRNA Inhibitor Library

A recent paper published by Micol Fiori et al. describes the use of Exiqon's microRNA library to screen for oncomiRs as therapeutic targets for treatment of lung cancer. One of the targets hsa-miR-197 was studied in detail.
Read the full paper

mRNA silencing in vitro and in vivo using LNA™ GapmeRs

mRNA silencing in vitro and in vivo using LNA™ GapmeRs

Anastasia Khvorova works at the RNA Therapeutics Institute at the University of Massachusetts Medical School. Her lab has been using LNA™ GapmeRs to silence two different genes which are valid therapeutic targets for neurodegenerative diseases.
Read more

New microRNA mimics

New microRNA mimics

Our sophisticated new 3rd generation microRNA mimics are ideal for simulating naturally occurring microRNAs. They feature an innovative triple RNA strand design which ensures that only the microRNA strand is loaded into the RISC complex, with no activity from the passenger strands. Read more

In vivo inhibition of lncRNA

In vivo inhibition of lncRNA

Katharina Michalik, Reinier Boon and Stefanie Dimmeler at Goethe University in Frankfurt are interested in microRNAs and long non-coding RNAs that control cardiovascular functions in endothelial cells. They have been using LNA™ GapmeRs to silence Malat1 in vitro and in vivo. Read more

Our microRNA inhibitors just got better

Our microRNA inhibitors just got better

Our miRCURY LNA™ microRNA Inhibitors and Power Inhibitors have been completely redesigned and updated to miRBase 20. We offer pre-designed inhibitors for virtually all human, mouse and rat in miRBase. Custom inhibitors are available for all other organisms. Read more

Featured article: miRNome-wide functional analysis

Featured article: miRNome-wide functional analysis

In a recent article published in PLOS ONE, Polesskaya and colleagues used a microRNA inhibitor library screen to discover and validate 63 microRNAs involved in muscle cell differentiation. The authors of this seminal paper present a novel strategy that can facilitate the functional annotation of the human miRNome. Read the paper

Free webinar: advances in gene silencing and lncRNA research

Free webinar: advances in gene silencing and lncRNA research

Join this free webinar to learn about: The new advanced tools for potent gene silencing in vitro and in vivo. The challenges of inhibiting long non-coding RNA and how to overcome them. The essentials of a successful RNA knockdown experiment using LNA™ GapmeRs. See it on demand

Free Science Webinar: Targeting non-coding RNA in disease

Free Science/AAAS Webinar: Targeting non-coding RNA in disease

Listen to Dr. Stephanie Dimmeler, Dr. Jan-Wilhelm Kornfeld and Dr. David Corey present the following topics: non-coding RNAs as therapeutic targets in human disease, the unique challenges of targeting functional RNA in vivo and recent advances enabling effective in vivo inhibition of non-coding RNA. See it on demand

5 tips for setting up a successful RNA inhibition experiment using gapmers

5 tips for setting up a successful RNA inhibition experiment using gapmers

What is most important to consider when setting up an RNA silencing experiment? How can you increase the chances of success? We have gathered the top tips for inhibition of mRNA and lncRNA using LNA™ GapmeRs.
View the tips

Inhibition of microRNA function: Challenges and opportunities

Inhibition of microRNA function: Challenges and opportunities

This webinar focuses on the challenges of microRNA inhibition and how to overcome them, the essentials of a successful microRNA inhibition experiment and the opportunities for analyzing microRNA function in vivo.
View the webinar

Top 5 tips for successful microRNA inhibition

Top 5 tips for successful microRNA inhibition

MicroRNA inhibition is a powerful technique for determining the function of a microRNA. Here, we have assembled five important tips for successful silencing experiments.

Learn more

Free Nature reprint collection: microRNA from bench to clinic

Free Nature reprint collection: microRNA from bench to clinic

This Nature Reprint Collection presents some of the recent advances in moving microRNAs from basic research into the clinic both as diagnostic biomarkers and therapeutic targets. Three of the articles focus on the potential of microRNAs as therapeutic targets in cardiovascular disease, diabetes and epilepsy. Get your free copy

Inside story: GapmeRs to silence lncRNA

Inside story: GapmeRs to silence lncRNA

Drs. Jean-Christophe Marine, Eleonora Leucci and Laura Standaert work at the Laboratory for Molecular Cancer Biology, K.U. Leuven in Belgium. They have been using LNA™ longRNA GapmeRs to silence non-coding RNAs linked to cancer.
Read about their exciting research

Sophisticated LNA™ GapmeR design tool online

Sophisticated LNA™ GapmeR design tool online

The advanced algorithm behind our highly successful gapmers is now available in an easy to use online tool. Use it to design potent antisense oligonucleotides for your mRNA or lncRNA target.
Try the tool

Solving the mystery of an unknown target gene with microRNA TSBs

Solving the mystery of an unknown target gene with microRNA TSBs

Dr. Virgine Mattot works in the team “Angiogenesis, endothelium activation and Cancer” directed by Dr. Fabrice Soncin at the Institut de Biologie de Lille. She has been using Target Site Blockers to investigate the role of microRNAs on putative targets which functions are yet unknown. Read about their exciting research

microRNA inhibitors and target site blockers

microRNA inhibitors and target site blockers

Find out more about our miRCURY LNA™ microRNA Inhibitor and Target Site Blockers based on the LNA™-technology for superior specificity and biostability.

Learn more

microRNA inhibition papers

View list of selected papers using microRNA inhibitors

Gapmer papers

View list of selected papers using LNA™ GapmeRs

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Get expert advice

We are happy to offer our expert advice and recommendations for all aspects of your microRNA project.


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