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Newsletter Back Issues
 
microRNA in biofluid

Since the discovery of extracellular microRNA only a few years ago, they have been detected in a large number of biofluids and it is becoming clear that these small regulating RNAs can be used as informative biomarkers to assess and monitor the physiopathological state of the body.

However, the study of microRNA in biofluids is challenging both due to the target and the samples involved and requires highly optimized reagents and protocols as well as strict attention to experimental procedure.

Did you just watch our seminar and wish to ask us something? Contact us



Impact of age, BMI and sex on circulating microRNA profile

Impact of age, BMI and sex on circulating microRNA profile

Researchers at the University of Greifswald in Germany have investigated the association between plasma microRNA profile and age, body mass index and sex. They used Exiqon's miRCURY Isolation Kit – Biofluids and miRCURY LNA™ Universal RT microRNA PCR system. Read the paper (external link)

Reliable Biofluids microRNA Sequencing Services

Reliable Biofluids microRNA Sequencing Services

A complete sample-to-answer microRNA-seq service from the people who pioneered microRNA biomarker discovery in liquid biopsies. We use RNA isolation and library preparation protocols specifically designed for biofluid samples to give optimal sequencing data with high mapping percentages. Learn more

Webinar: microRNA profiling in liquid biopsies by qPCR and NGS

Webinar: microRNA profiling in liquid biopsies by qPCR and NGS

Watch our recent webinar to hear our valuable tips gained from years of experience profiling microRNAs in biofluid samples.

Watch on demand

Top 5 Tips: microRNA NGS in serum/plasma

Top 5 Tips: microRNA NGS in serum/plasma

Exiqon's pioneering work with biofluids has enabled Exiqon Services to develop sample handling recommendations and optimized protocols for NGS in biofluids to ensure reliable results.
Read the Top 5 tips

Genome-wide comparison of NGS and qPCR for biofluids microRNA profiling

Genome-wide comparison of NGS and qPCR for biofluids microRNA profiling

We put qPCR and NGS to the test, using microRNA protocols optimized specifically for biofluid samples, to analyze the same liquid biopsy serum samples on both platforms. Find out how many microRNAs were detected by each platform, how the results compare, and why validation is important. Download the TechNote

Top 5 Tips: RNA isolation from biofluids

Top 5 Tips: RNA isolation from biofluids

Identifying RNA biomarkers in biofluids holds great promise but can be challenging. These samples often contain tiny amounts of RNA and are subject to contamination during handling. We have assembled some of our best tips to let you get the most out of your samples. Read the Top 5 tips

New biomarkers in biofluids

New biomarkers in biofluids

  • The potential of microRNA as biomarkers
  • Challenges and solutions for profiling microRNAs in biofluids
  • Our recent progress in discovery and validation of microRNA biomarkers for prostate and colorectal cancer See the presentation
New exosome presentation based on our AACR poster

New exosome presentation based on our AACR poster

Learn how to isolate and profile exosome microRNAs from common biofluids. Get valuable tips on how to set up your experiment and see an example of how microRNA profiles from urine can be used to identify the various stages of prostate cancer.
See the presentation

Independent study shows Exiqon’s biofluid kit outperforms competitors

Independent study shows Exiqon’s biofluid kit outperforms competitors

Researchers at The Johns Hopkins University School of Medicine have compared the performance of Exiqon’s miRCURY™ RNA isolation kit – Biofluids to other commercially available RNA isolation methods and found that it offers the best combination of performance and ease-of-use. Read the paper (external link)

exosome isolation kit

New Exosome Isolation Kits

High quality exosome isolation using a fast protocol for scalable isolation of exosmes from various biofluids. Exosome isolation using miRCURY™ Exosome Isolation Kits ensures seamless integration with the miRCURY™ RNA Isolation Kits and miRCURY LNA™ Universal RT microRNA PCR system. Learn more

Exosome Focus microRNA PCR Panels

Exosome Focus microRNA PCR Panels

PCR panels containing miRCURY LNA™ Universal RT microRNA PCR assays for microRNAs typically found in exosomes. Panels are available in ready-to-use 96 and 384 well plates – just add cDNA and PCR master mix.
Learn more

microRNA profiling from 1µL serum

microRNA profiling from 1µL serum

In order to identify potential microRNA biomarkers for asthma, a mouse model for asthmatic response was used for microRNA profiling. RNA from the equivalent of 1µL serum was enough to profile over 120 mouse microRNAs on the miRCURY LNA™ Serum/Plasma Focus Panels. Read the story

microRNAs in urine

microRNA profiling in urine

This white paper describes the discovery of microRNA biomarkers of kidney damage in urine samples. Learn about: setting up microRNA profiling studies in urine, strategies for normalization and data analysis and how to Identify microRNA-based markers of kidney damage. Read the paper

microRNAs in serum/plasma

Introduction to microRNA in biofluids

microRNAs have been detected in many different biofluids. It has also been shown that extracellular or circulating microRNAs can be biomarkers for a variety of disease. Exiqon offers a range of products specifically well suited to the analysis of microRNA in Biofluids. Find out more

Challenges and solutions

Updated microRNA profiling guidelines: New edition available

Biofluid samples are challenging due to their limited RNA content and susceptibility to effects of pre-analytical variables. The guidelines provide important information and tips to ensure successful microRNA profiling in serum/plasma and other biofluids using microRNA qPCR. Download guidelines

Recommendations for sample collection and handling

Recommendations for sample collection and handling

In order to ensure high quality samples that perform well in downstream analysis, it is important to pay special attention to the way biofluid samples are collected and handled.

Read more

Webinar

Webinar: microRNA in biofluids

Watch the webinar and learn about: the challenges of microRNA profiling in biofluids, the essentials of developing robust biomarkers in serum/plasma and urine and our recent progress in discovery and validation of microRNA biomarkers for disease and organ damage. View the webinar

Small RNA isolation from Biofluids

Small RNA isolation from Biofluids

Exiqon’s miRCURY RNA Isolation kit – Biofluids is the first RNA purification kit on the market to be optimized for biofluids. Find out more about this easy-to-use kit for isolating high quality microRNA from samples with limited RNA content.
Read more

Science webinar: Detecting Disease in Blood

Webinar: Detecting Disease in Blood

This webinar featuring Dr. Colin Pritchard from the University if Washington and Dr. Monty Montano from Boston University School of Medicine presents some of the latest advances in blood based miRNA biomarker research.
View the webinar

microRNA Application Stories

Inside story: microRNA profiling in biofluids

Learn about microRNA profiling in biofluid samples from experienced microRNA researchers and their current projects. Get useful hints and advice for your own profiling study.
Read the exciting application stories

PCR Focus panels for Toxicology and Serum/Plasma

The ideal microRNA PCR system for biofluids

Exiqon's highly sensitive qPCR system is ideal for microRNA profiling from biofluids. Choose between individual assays, miRNome panels, Focus panels and custom plates.
Read more
View movie: The ideal microRNA PCR system

Exiqon Services

Let Exiqon Services perform your microRNA profiling

Our expert scientists can perform biofluid microRNA profiling tailored to your research needs and budget.
Read more
View movie about Exiqon services

Study recommends Exiqon's biofluids kit

Researchers at Johns Hopkins compared the performance of the miRCURY™ RNA isolation kit to other commercially available RNA isolation methods

Paper recommends Exiqon for plasma

In a recent BMC Genomics paper benchmarking two microRNA qPCR platforms Exiqon's system came out on top.

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We are happy to offer our expert advice and recommendations for all aspects of your microRNA project.


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