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microRNA Antisense Controls

Negative control inhibitors for quality assessment of your in vitro microRNA inhibition experiment.

  • Similar in length of sequence and LNA™ design to our miRCURY LNA™ microRNA Inhibitor and Power Inhibitor
  • No homology to any known microRNA or mRNA sequences in mouse, rat or human

Coverage

We currently offer four pre-designed negative controls for the miRCURY LNA™ microRNA Inhibitors - two miRCURY LNA™ microRNA Inhibitor Negative Controls and two miRCURY LNA™ microRNA Power Inhibitor Negative Controls with the phosphorothioate backbone to match the miRCURY LNA™ microRNA Power Inhibitors.

For each of the inhibitor product categories we have the following two microRNA inhibitor control offerings:
  • Negative Control A (identical to the former Scramble-miR control): No hits of >70% homology to any sequence in any organism in the NCBI and miRBase databases.
  • Negative Control B (identical to the former Sense miR-159 control): No hits of >70% homology to any human, mouse or rat sequence in the NCBI and miRBase databases. Not recommended for use in plants.
The inhibitor controls are desalted and delivered dried down in tubes. Once dissolved they are ready for transfection or electroporation using standard techniques.

A choice of three different product categories is offered in three different amounts (1 nmol, 5 nmol and 15 nmol) and they are also available with fluorescein (6-FAM) labels:
  • miRCURY LNA™ microRNA Inhibitors Pre-designed LNA™-enhanced microRNA inhibitors. These DNA/LNA™ mixmer antisense oligonucleotides have normal phosphodiester nucleotide bonds.
  • miRCURY LNA™ microRNA Power Inhibitors Power inhibitors have a fully phosphorothioate (PS) modified backbone which makes them highly resistant to enzymatic degradation. As a result they have superior potency and greatly increased stability. In fact efficient inhibition of microRNA activity can be achieved by simple addition of Power inhibitors directly to cell cultures. This allows you to study the consequences of microRNA silencing without worrying about confounding side effects deriving from the transfection reagents. In all other respects this class of inhibitors is identical to our regular line of microRNA inhibitors.
  • Custom miRCURY LNA™ microRNA Inhibitors In case you wish a mismatched negative control specific to a particular microRNA inhibitor than Exiqon can design it for you. Read more at Custom miRCURY LNA™ microRNA Inhibitors.
To view the sequences of the microRNA inhibitor controls, please click on your product of interest in the table below.

Xavier Gidrol

High content microRNA inhibitor screening with cell arrays


"...thanks to the LNA™ microRNA inhibitor screen, we have discovered several new miRNAs playing a major role in the regulation of the proliferation/differentiation balance in prostate cells."

Dr. Xavier Gidrol directs the Biomics Laboratory at the Institute of Life Science Research and Technologies in Grenoble, France. They use microfluidics, micromanufacturing and MEMS to study the impact of genetic and micro-environmental determinants on carcinogenesis, at the scale of a few or even single cells. Xavier has used minute cell microarrays to perform high throughput and high content screening with our human library of microRNA inhibitors in primary prostate cancer cells extracted from patients.

Read full story...

Amy Hansen

Viral microRNAs Involved in Cell Reprogramming


"Previously, we had tried other inhibitor designs but these gave inconclusive results."

Amy Hansen is a Ph.D student at the University College London. She works in the Cancer Research UK Viral Oncology Group lead by Professor Chris Boshoff, Director of the UCL Cancer Institute.

Read full story...

Dr. Annick Harel-Bellan

MicroRNAs and Muscle Cell Differentiation


"LNA microRNA antisense inhibitors are efficient and specific with long lasting effects."

Dr. Annick Harel-Bellan (AHB) is Directeur de Recherche at the Institut Andre Lwoff in Paris. She heads a group working on epigenetics and cancer (Laboratoire Epigenetique et Cancer). Dr. Anna Polesskaya (AP) is a senior scientist and longstanding member of this group.

Read full story...

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Showing 1 - 20 of 20 products
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Prod. No.
Product Name
Description Notes
199006-000 Negative control A miRCURY LNA™ microRNA inhibitor control, 1 nmol
199006-001 Negative control A miRCURY LNA™ microRNA inhibitor control, 5 nmol
199006-002 Negative control A miRCURY LNA™ microRNA inhibitor control, 15 nmol
199006-011 Negative control A miRCURY LNA™ microRNA inhibitor control, 5nmol, 5`-fluorescein labeled
199006-021 Negative control A miRCURY LNA™ microRNA inhibitor control, 5nmol, 3`-fluorescein labeled
199007-000 Negative control B miRCURY LNA™ microRNA inhibitor control, 1 nmol
199007-001 Negative control B miRCURY LNA™ microRNA inhibitor control, 5 nmol
199007-002 Negative control B miRCURY LNA™ microRNA inhibitor control, 15 nmol
199007-011 Negative control B miRCURY LNA™ microRNA inhibitor control, 5nmol, 5`-fluorescein labeled
199007-021 Negative control B miRCURY LNA™ microRNA inhibitor control, 5nmol, 3`-fluorescein labeled
199006-100 Negative control A miRCURY LNA™ Power microRNA inhibitor control, 1 nmol
199006-101 Negative control A miRCURY LNA™ Power microRNA inhibitor control, 5 nmol
199006-102 Negative control A miRCURY LNA™ Power microRNA inhibitor control, 15 nmol
199006-111 Negative control A miRCURY LNA™ Power microRNA inhibitor control, 5nmol, 5`-fluorescein labeled
199006-121 Negative control A miRCURY LNA™ Power microRNA inhibitor control, 5nmol, 3`-fluorescein labeled
199007-100 Negative control B miRCURY LNA™ Power microRNA inhibitor control, 1 nmol
199007-101 Negative control B miRCURY LNA™ Power microRNA inhibitor control, 5 nmol
199007-102 Negative control B miRCURY LNA™ Power microRNA inhibitor control, 15 nmol
199007-111 Negative control B miRCURY LNA™ Power microRNA inhibitor control, 5nmol, 5`-fluorescein labeled
199007-121 Negative control B miRCURY LNA™ Power microRNA inhibitor control, 5nmol, 3`-fluorescein labeled
 
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