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Custom miRCURY LNA™ microRNA Detection Probes

Take advantage of Exiqon’s expertise in designing LNA™-enhanced detection probes targeting custom RNA sequences.

  • Unmatched detection of small RNA molecules by in situ hybridization and Northern blotting
  • Superior specificity and sensitivity
  • Designed by our expert team for optimal LNA™ content and positioning
  • Minimal secondary structure and self-complementarity
  • Ideal for standardized protocols in automated High-Throughput ISH
  • Fast and easy produre – optimized for use with the One-day microRNA ISH protocol and buffer kits

LNA™-enhanced custom probes for optimal detection of any microRNA

Custom miRCURY LNA™ microRNA Detection probes for Northern Blotting are available for specific detection of novel microRNAs, microRNAs not covered by any pre-designed miRCURY LNA™ microRNA Detection probes, or other short ncRNA sequences. These custom microRNA detection probes are designed by our technical support scientists applying the same design rules used with our pre-designed microRNA detection probes.

The custom miRCURY LNA™ microRNA Detection probes are designed with optimal LNA™ positioning to achieve high sequence specificity, low secondary structure and minimal self-annealing. For Northern Blotting, this results in probes with very high binding affinity, single-nucleotide discrimination and remarkable signal-to-noise ratios, resulting in highly specific and sensitive microRNA detection.

Content

The custom miRCURY LNA™ microRNA Detection probes are available in two different amounts (1 nmol and 10 nmol), and with a variety of 3’-end, 5’-end, or double (3’ and 5’) labeling options: DIG, biotin, fluorescein, amino, TYE563 and TYE665. “Ready-to-label” probes designed for custom labeling are also available. For ordering, price information and requests for alternative labels, please contact us.

Higher sensitivity with double-labeled probes

For researchers who wish to detect microRNAs on Northern blots by non-radioactive methods, we recommend the use of double (3’ and 5’) DIG-labeled or fluorescein probes.

Note

Before submitting your order, please check if a pre-designed miRCURY LNA™ microRNA Detection probe targeting your sequence is available. Pre-designed miRCURY LNA™ microRNA Detection Probes are available for most microRNA sequences annotated in miRBase.



Liming Luan

MicroRNAs in Skin


"Exiqon is one of the leading suppliers for miRNA-related products."

Dr. Liming Luan at Vanderbilt University Medical Center in Nashville studies the role of microRNAs in normal and pathological conditions of the skin.

Read full story...

Mircea Ivan

MicroRNAs in Hypoxia


"I was intrigued by this interesting technology, which is very different from other available technologies."

Dr. Mircea Ivan at Indiana University School of Medicine studies the role of microRNAs in hypoxia. Here he describes why his lab chose Exiqon's detection probes.

Read full story...

Ronald H. A. Plasterk

MicroRNA Involvment in Embryo Development


"We got some beautiful data and spectacular images. We generated a complete catalogue of images showing the temporal and spatial expression patterns of 115 conserved microRNAs in zebrafish embryos."

Prof Ronald H. A. Plasterk, Hubrecht Laboratory, The Netherlands.

Read full story...

Dylan Sweetman

MicroRNAs in Muscle Cell Differentiation


"Following the success of LNA™ probes as demonstrated in Plasterk's lab, we decided to take the same approach."

Dr. Dylan Sweetman is working in Dr. Andrea Münsterberg’s group at the University of East Anglia, School of Biological Sciences. The group investigates cellular and molecular mechanisms that underlie embryonic development.

Read full story...

Parker Antin

MicroRNAs and Early Embryonic Development


"LNA™ technology is superior to any other for the detection of small RNA species."

Dr. Parker Antin's lab at the University of Arizona runs a large scale in situ hybridization database project to determine the expression patterns for all differentially expressed genes in the chicken embryo. Find out what the challenges were with this huge project and how they were overcome.

Read full story...

This is a custom LNA™ product. Please contact us for further information and ordering.
Our global technical support team will respond within 2 business days.
 
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