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KRAS Mutation Analysis
BRAF Mutation Analysis
Published Studies
Chemotherapy Resistance and Oncogene Expression in Non-Small Cell Lung Cancer
Thomas A. d'Amato, MD, PhD, Rodney J Landreneau, MD, William Ricketts, PhD, Weidong Huang, MD, PhD, Ricardo Parker, PhD, Eugene Mechetner, MD, Ing-Ru Yu, MS, and James D. Luketich, MD
Journal of Thoracic and Cardiovascular Surgery, 2007, 133:  352-363
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Biomarker Expression Profiles in Primary versus Metastatic Colorectal Tumors
Ing-Ru Yu, Ricardo J. Parker, and Eugene Mechetner. Oncotech Inc., Tustin, CA.
American Association for Cancer Research, 2007, Abstract:  #196
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Biomarker and In Vitro Chemoresistance Profiles of Undifferentiated Ovarian Cancers
John Chan1, Jacob Shin1, Daniel Kapp1, Eugene Mechetner2, and Ing-Ru Yu2.
1Stanford University, Stanford, CA., 2Oncotech Inc., Tustin, CA.

American Association for Cancer Research, 2007, Abstract:  #3488
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In Vitro Testing of Drug Cross-Resistance to Improve Standard Combination Chemotherapy Selection in Colorectal Cancer
Ing-Ru Yu, M.S., Ricardo Parker, Ph.D., and Eugene Mechetner, Ph.D., Oncotech, Inc., Tustin, CA.
Association of Colon and Rectal Surgeons (ASCRS), 2007, Abstract:  #A125
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Differential Gene Expression Associated with Early Tumor Recurrence and Long Disease Free Survival in Early Stage Non-Small Cell Lung Cancer
1T.A. d’Amato, 2H.C. Fernando, 3B.Y. Chan, 4W.A. Ricketts, 5J.D. Luketich, 5R.J. Landreneau.
1Department of Surgery, Jefferson Medical College, Philadelphia, PA; 2Boston Medical Center, Boston, MA; 3UC Irvine, Irvine, CA; 4Oncotech Inc., Tustin, CA, 5University of Pittsburgh Medical Center, Pittsburgh, PA.
The Society of Surgical Oncology (SSO), 2007, Abstract:  #140
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In Vitro Drug Resistance Profiles and Biomarker Expression in 414 Freshly Resected Esophageal Cancer Specimens
Ing-Ru Yu, Ricardo Parker, and Eugene Mechetner. Oncotech Inc., Tustin, CA.
The Society of Surgical Oncology (SSO), 2007, Abstract:  #244
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In Vitro Drug Resistance Profiles Correlate with DNA Ploidy and p53 Expression in 3,106 Endometrioid and Papillary Serous Adenocarcinomas of the Uterus
Ing-Ru Yu, Weidong Huang, and Eugene Mechetner. Oncotech Inc., Tustin, CA.

Proc. of American Society of Clinical Oncology, 2006, Abstract # 5037:  1
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Correlating Signal Transduction Protein Kinase Levels, SNPs and Drug Resistance in Human Melanoma
1David L. Smith, 2Michael van Waes and 1William A. Ricketts. 1Oncotech Inc., Tustin, CA.
2LI-COR Biosciences, Lincoln, NE.

American Association for Cancer Research (AACR), 2006, Abstract #925:  1
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Detecting Altered Expression and Activation of Signaling Pathways in Cisplatin Resistant Ovarian Cancer
Snjezana Covic, David L. Smith, and William A. Ricketts. Oncotech, Inc., Tustin, CA.

American Association for Cancer Research (AACR), 2006, Abstract #5089:  1
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Detecting Altered Expression and Activation of Signaling Pathways in Cisplatin Resistant Ovarian Cancer
Snjezana Covic, David L. Smith, and William A. Ricketts. Oncotech, Inc., Tustin, CA.

American Association for Cancer Research (AACR), 2006, Abstract #5089:  1
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Morphological and Immunohistochemical Assessment of In Vitro Cell Proliferation of Fresh Human Tumor Tissues in an Agarose-Based Assay
Weidong Huang M.D., Ph.D., Yen Huynh, Linda Hiroshima, Dennis Bansil, Ing-Ru Yu M.S., Lilian Tee. Oncotech Inc., Tustin, CA.

American Association for Cancer Research (AACR), 2006, Abstract #5432:  1
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Identification of Amplifications and Deletions in Taxol Resistant Ovarian Cancer by Comparative Genomic Hybridization Screening
David Smith, Bejan Shahbahrami, Snjezana Covic, William Ricketts, Oncotech, Inc., Tustin, CA.

SGO 2006 Annual Meeting, 2006, Abstract #799:  1
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A 96-well Soft Agar Based Assay for Testing Cell Lines and Tumors
Alessandra Re and William A. Ricketts. Oncotech Inc., Tustin, CA.

American Association for Cancer Research (AACR), 2006, Abstract #1363:  1
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Association of DNA Ploidy and p53 Expression with 5-FU, CPT-11, and Oxaliplatin Resistance in the EDR Assay: A Study of 1,271 Colon Adenocarcinomas
Weidong Huang, M.D., Ph.D., Ing-Ru Yu, Eugene Mechetner, Ph.D.,
Oncotech, Inc., Tustin, CA
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Optimization of protocols and screening of Topoisomerase II-alpha for SNPs that predict response to etoposide and doxorubicin
David L. Smith, William A. Ricketts and Michael van Waes. 1. Oncotech Inc, 15501 Red Hill Avenue, Tustin CA 92780 2. LI-COR Biosciences, 4308 Progressive Avenue, Lincoln NE 68504.
American Association for Cancer Research (AACR), 2005, Abstract #4457:  1
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In Vitro Extreme Chemotherapy Resistance Patterns for Resected Non-Small Cell Lung Cancer
T. d'Amato1, *R. Landreneau2, *R. McKenna3, R. Santos2, R. Parker4
1University of California, San Diego, San Diego, CA, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3Cedar Sinai Medical Center, Los Angeles, CA, 4Oncotech Inc, Tustin, CA.
Annals of Thoracic Surgery, 2005, Abstract #42:  1
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The Possible Role of Chemoresistance Testing in the Era of Post Surgical Adjuvant Chemotherapy for Non-Small Cell Lung Cancer (NSCLC)
Ricardo S. Santos, M.D*., Amit N. Patel, M.D., Clark T. Gamblin, M.D., Hiran C. Fernando, M.D., James D. Luketich, M.D. and Rodney J. Landreneau, M.D. University of Pittsburgh Medical Center, Pittsburgh, PA.
CHEST 2004 Meeting, 2004, Abstract #1188:  1
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A Prospective Blinded Study of Predictive Value of Extreme Drug Resistance Assay in Patients Receiving CPT-11 for Recurrent Glioma
Ricardo J. Parker, John P. Fruehauf, Rita Mehta, Emese Filka, and Timothy Cloughesy
Journal of Neuro-Oncology, 2004, 66:  365-375
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Survival outcomes in patients with recurrent ovarian cancer who were treated with chemoresistance assay-guided chemotherapy
Vera Loizzi, John K Chan, Kathryn Osann, Fabio Cappuccini, Phillip J DiSaia, and Michael L Berman.
American Journal of Obstetrics and Gynecology, 2003, 189, number 5:  1301-1307
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In Vitro Chemoresistance and Biomarker Profiles are Unique for Histologic Subtypes of Epithelial Ovarian Cancer
Noelle G Cloven*, Ainura Kyshtoobayeva, Robert A Burger, Ing-Ru Yu, John P Fruehauf.
Gynecologic Oncology, 2004, 92:  160-166
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In Vitro and Ex Vivo Activity of SDX-105 (Bendamustine) in Drug-Resistant Lymphoma cells
Lorenzo M. Leoni, Brandi Bailey, Christina C. Niemeyer, Jack Reifert, Heather Bendall, Lisa Dauffenbach, and Christopher Kerfoot.
American Association for Cancer Research (AACR), 2004, Abstract #1215:  1
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In Vitro Dosing Schedules in Breast and Ovarian Cancer and the Relationship with Topoisomerase I Expression
Christopher Kerfoot, Lisa Dauffenbach, Weidong Huang, John Fruehauf.
American Association for Cancer Research (AACR), 2004, Abstract #5387:  1
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CD117/KIT Expression and Alkylator Resistance in Solid Tumors
John Fruehauf, Ainura Kyshtoobayeva, and Ing-Ru Yu.
American Association for Cancer Research (AACR), 2004, Abstract #1219:  1
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Antiangiogenesis Activity of Buthionine Sulfoximine (BSO) Related to Glutathione Depletion and Dynein Overexpression
John P. Fruehauf, Lillian Tee, Carina Torres, and Lisa Dauffenbach.
American Association for Cancer Research (AACR), 2004, Abstract #59:  1
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In Vitro Activity of Tarceva™ in Primary Lung And Colon Cancer Cells
Christopher A. Kerfoot, James Thompson, Michael Richardson, Deborah Pavich, Sunjay S. Ramsinghani, Audrey Goddard, David A. Eberhard.
American Association for Cancer Research (AACR), 2003, Abstract R3796:  1
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Application of Surface-Enhanced Laser Desorption/Ionization Technology to Discover Ovarian Cancer Biomarkers for Early Detection and Individualized Treatment
Bejan Shahbahrami, Carina Torres, Lan Huynh, and John P. Fruehauf.
American Association for Cancer Research (AACR), 2003, Abstract # 5986:  1
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Enhanced Antimelanoma Activity After Exposure to BSO in Combination with Disulfiram
Carina Torres, John P. Fruehauf, Lan Huynh, and Ricardo Parker.
American Association for Cancer Research (AACR), 2003, Abstract # 4643:  1
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Distinct Intrinsic and Dynamic Gene Expression Profiles Associated with Taxane Response in Breast and Ovarian Cancer
john P. Fruehauf, Lisa Dauffenbach, Carina Torres, and Mike Petka.
American Association for Cancer Research (AACR), 2003, Abstract # 3998:  1
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Endothelial Cells Co-Cultured with Breast or Ovarian Cancer Demonstrated Differential Gene Expression and Apoptotic Response
Lisa Dauffenbach, Carina Torres, and John Fruehauf.
American Association for Cancer Research (AACR), 2003, Abstract # 3325:  1
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Correlation of Tumor-Associated Biomarkers with In Vitro Drug Response (IVDR) in Malignant Gliomas
Ricardo J. Parker, Raymond Haroun, Richard Clatterbuck, Chris Gibbons, Henry Brem, Steven Brem, Andrew Sloane, Geoffrey Barger, and John P. Fruehauf.
American Association for Cancer Research (AACR), 2003, Abstract # 2550:  1
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Development of an in Vitro Chemo-Radiation Response Assay for Cervical Carcinoma
Bradley J. Monk, M.D., Robert A. Burger, M.D., Ricardo Parker, Ph.D., Eric H. Radany, M.D., Ph.D., Leslie Redpath, Ph.D., John P. Fruehauf, M.D., Ph.D.
Gynecologic Oncology, 2002, 87:  193-199
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Survival and Response Rates in Refractory Ovarian Cancer Treated with Chemoresistance Assay Guided Chemotherapy
Vera Loizzi, John K Chan, Fabio Cappuccini, Kathryn Osann, Phillip J DiSaia, Michael L Berman.
International Gynecologic Cancer Society, 2002, Abstract #OV110:  1
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Association Between In Vitro Platinum Resistance in the EDR Assay and Clinical Outcomes for Ovarian Cancer Patients
Robert W. Holloway, M.D., Rita S. Mehta, M.D., Neil J. Finkler, M.D., Kuo-Tung Li, M.S., Christine E. McLaren, Ph.D., Ricardo J. Parker, Ph.D., John P. Fruehauf, M.D., Ph.D.
Gynecologic Oncology, 2002, 87:1:  8-16
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In vitro assay-assisted treatment selection for women with breast or ovarian cancer
JP Fruehauf
Endocrine-Related Cancer, 2002, 9:  171-182
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In Vitro Drug Response and Biomarker Profiles for Ovarian Cancer Specimens Obtained at Initial Debulking or after Neoadjuvant Chemotherapy (EORTC 55971)
John P. Fruehauf, Ing-Ru Yu, Ricardo Parker
American Society of Clinical Oncology, 2002, Abstract #2177:  1
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Antiangiogenesis Effects of Docetaxel and L-Buthionine-S, R-Sulfoximine (BSO) on Tumor Derived Vascular Endothelial Cells
Carina Torres, Ricardo Parker and John P. Fruehauf.
American Association for Cancer Research, 2002, Abstract #3920:  1
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Differential Gene Expression Analysis Genetically Fingerprints Tumors of Unknown Primary
John P. Fruehauf, Ainura Kyshtoobayeva, Ing-Ru Yu, Debbie Pavich, Carina Torres, Kristin McGann, Bob Chan, Michael Petka, Patty Pang and Frank J. Kiesner
American Association for Cancer Research, 2002, Abstract #4502:  1
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The Relationship of Molecular Markers of p53 Function and Angiogenesis to Prognosis of Stage I Epithelial Ovarian Cancer
Michael J Goodheart*, Stephen Rose, Justine M Ritchie, John P Fruehauf, Barry R Deyoung, Richard E Buller.
SGO 33rd Annual Meeting, 2002, Abstract #77:  1
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Breast cancer survival and in vitro tumor response in the extreme drug resistance assay
Rita S. Mehta, Richard Bornstein, Ing-Ru Yu, Ricardo J. Parker, Christine E. McLaren, Khanh P. Nguyen, Kuo-Tung Li, and
John P. Fruehauf
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Significant Association between Angiogenesis Index and Survival in Colorectal Cancer
Edward A Wagner, M.D., Tammey J Naab, M.D., Ricardo J Parker, Ph.D., Rita S Mehta, M.D., Wayne Tuckson, M.D., Christine E McLaren, Ph.D., Khan Nguyen, Fitzroy Dawkins, M.D., A. Kyshtoobayeva, M.D., John P Fruehauf, M.D., Ph.D.
American Association for Cancer Research, 2000, Abstract # 1075:  1
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High Throughput Screening for MDR1 Substrate Specificity Using the MDR1 Shift Assay
E. Mechetner, Ph.D., L. Tee, S.W. Park, J.P. Fruehauf, M.D., Ph.D.
American Association for Cancer Research, 2000, Abstract #656:  1
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In Vitro Drug Resistance Patterns in Epithelial Ovarian Cancer
Krishnansu S Tewari, Rita S Mehta, Ingru-Yu, Ainura S Kyshtoobayeva, Alberto Manetta, John P Fruehauf.
SGO 32nd Annual Meeting, 2001, Abstract #143:  1
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Gene Array Analysis of In Vitro Drug Response
Eugene Mechetner, John P. Fruehauf, Shubhra Mittal, Bejan Shabahrami, Deborah Pavich, Lillian Tee, Carina Torres.
American Association for Cancer Research, 2001, Abstract #2599:  1
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Gene Array Analysis of Endothelial Cells Isolated from Human Tumors: A New Approach to the Development of Antiangiogenesis Therapies
Eugene Mechetner, John P. Fruehauf, Shubhra Mittal, Bejan Shabahrami, Deborah Pavich, Lillian Tee, Carina Torres.
American Association for Cancer Research, 2001, Abstract #3041:  1
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