Specific telomere detection using LNA™ FISH probes.
Image kindly provided by Dr. R. W. Dirks, Leiden University Medical Center, Leiden, The Netherlands |
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Comparison of LNA™ (A) and DNA (B) probes in FISH for the human satellite-2 repeat. The use of a Cy3-labelled LNA™ substituted FISH probe results in strong hybridisation signals on chromosomes 1, 9, 15 and 16, respectively, after hybridisation for 30 min at 37°C (A), whereas no signals can be detected with the DNA FISH probe (B).
Images were kindly provided by A. Silahtaroglu, University of Copenhagen, Denmark. |
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